2018
González-Marrón A, Martín-Sánchez JC, Matilla-Santander N, Cartanyà-Hueso À, Lidón-Moyano C, Vidal C, García M, Martínez-Sánchez JM.
Estimation of the adult population at high risk of developing lung cancer in the European Union. Journal Article
Cancer Epidemiol. 2018;57:140–147.
Abstract | Links | BibTeX | Tags:
@article{pmid30497060,
title = {Estimation of the adult population at high risk of developing lung cancer in the European Union},
author = {González-Marrón A and Martín-Sánchez JC and Matilla-Santander N and Cartanyà-Hueso À and Lidón-Moyano C and Vidal C and García M and Martínez-Sánchez JM},
doi = {10.1016/j.canep.2018.10.007},
issn = {1877-783X},
year = {2018},
date = {2018-12-01},
journal = {Cancer Epidemiol},
volume = {57},
pages = {140--147},
abstract = {Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n = 27,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n = 27,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.
Del Pozo MDP, Castelló A, Vidal C, Salas-Trejo D, Sánchez-Contador C, Pedraz-Pingarrón C, Moreo P, Santamariña C, Ederra M, Llobet R, Vioque J, Pérez-Gómez B, Pollán M, Lope V.
Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study. Journal Article
Maturitas. 2018;117:57–63.
Abstract | Links | BibTeX | Tags:
@article{pmid30314562,
title = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},
author = {Del Pozo MDP and Castelló A and Vidal C and Salas-Trejo D and Sánchez-Contador C and Pedraz-Pingarrón C and Moreo P and Santamariña C and Ederra M and Llobet R and Vioque J and Pérez-Gómez B and Pollán M and Lope V},
doi = {10.1016/j.maturitas.2018.09.006},
issn = {1873-4111},
year = {2018},
date = {2018-11-01},
journal = {Maturitas},
volume = {117},
pages = {57--63},
abstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.
Guillamó E, Cobo-Calvo Á, Oviedo GR, Travier N, Álamo J, Niño-Mendez OA, Martínez-Yelamos A, Martínez-Yelamos S, Javierre C.
Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article
J Sports Sci Med. 2018;17:426–436.
@article{pmid30116116,
title = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},
author = {Guillamó E and Cobo-Calvo Á and Oviedo GR and Travier N and Álamo J and Niño-Mendez OA and Martínez-Yelamos A and Martínez-Yelamos S and Javierre C},
issn = {1303-2968},
year = {2018},
date = {2018-09-01},
journal = {J Sports Sci Med},
volume = {17},
number = {3},
pages = {426--436},
abstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.
Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peiró I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Muñoz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A.
Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors. Journal Article
Eur J Cancer Care (Engl). 2018;27:e12861.
Abstract | Links | BibTeX | Tags:
@article{pmid29869823,
title = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},
author = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peiró I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Muñoz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},
doi = {10.1111/ecc.12861},
issn = {1365-2354},
year = {2018},
date = {2018-07-01},
journal = {Eur J Cancer Care (Engl)},
volume = {27},
number = {4},
pages = {e12861},
abstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12 weeks to 42 overweight/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32 ≤ |r| ≤ 0.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12 weeks to 42 overweight/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32 ≤ |r| ≤ 0.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.
Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ, Vernet M, Saladié F, Romero A, Sánchez M, Baré M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodríguez-Arana A, Castells X, study BELE Project group.
Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Journal Article
Breast J. 2018;24:509–518.
Abstract | Links | BibTeX | Tags:
@article{pmid29517151,
title = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},
author = {Román M and Caicoya M and Espinàs J and Sala M and Torá-Rocamora I and Quinta MJ and Vernet M and Saladié F and Romero A and Sánchez M and Baré M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodríguez-Arana A and Castells X and BELE Project study group},
doi = {10.1111/tbj.13003},
issn = {1524-4741},
year = {2018},
date = {2018-07-01},
journal = {Breast J},
volume = {24},
number = {4},
pages = {509--518},
abstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group.
The IARC Perspective on Colorectal Cancer Screening. Journal Article
N Engl J Med. 2018;378:1734–1740.
@article{pmid29580179,
title = {The IARC Perspective on Colorectal Cancer Screening},
author = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},
doi = {10.1056/NEJMsr1714643},
issn = {1533-4406},
year = {2018},
date = {2018-05-01},
journal = {N Engl J Med},
volume = {378},
number = {18},
pages = {1734--1740},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Fernández-Navarro P, Altzibar JM, González-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tardón A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Castaño-Vinyals G, Ederra M, Vilorio-Marqués L, Amiano P, Pérez-Gómez B, Aragonés N, Kogevinas M, Pollán M, Llorca J.
Validating a breast cancer score in Spanish women. The MCC-Spain study. Journal Article
Sci Rep. 2018;8:3036.
Abstract | Links | BibTeX | Tags:
@article{pmid29445177,
title = {Validating a breast cancer score in Spanish women. The MCC-Spain study},
author = {Dierssen-Sotos T and Gómez-Acebo I and Palazuelos C and Fernández-Navarro P and Altzibar JM and González-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tardón A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Castaño-Vinyals G and Ederra M and Vilorio-Marqués L and Amiano P and Pérez-Gómez B and Aragonés N and Kogevinas M and Pollán M and Llorca J},
doi = {10.1038/s41598-018-20832-0},
issn = {2045-2322},
year = {2018},
date = {2018-02-01},
journal = {Sci Rep},
volume = {8},
number = {1},
pages = {3036},
abstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI = 0.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI = 0.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.
Lope V, García-Pérez J, Pérez-Gómez B, Pedraza-Flechas AM, Alguacil J, González-Galarzo MC, Alba MA, van der Haar R, Cortés-Barragán RA, Pedraz-Pingarrón C, Moreo P, Santamariña C, Ederra M, Vidal C, Salas-Trejo D, Sánchez-Contador C, Llobet R, Pollán M.
Occupational exposures and mammographic density in Spanish women. Journal Article
Occup Environ Med. 2018;75:124–131.
Abstract | Links | BibTeX | Tags:
@article{pmid29074552,
title = {Occupational exposures and mammographic density in Spanish women},
author = {Lope V and García-Pérez J and Pérez-Gómez B and Pedraza-Flechas AM and Alguacil J and González-Galarzo MC and Alba MA and van der Haar R and Cortés-Barragán RA and Pedraz-Pingarrón C and Moreo P and Santamariña C and Ederra M and Vidal C and Salas-Trejo D and Sánchez-Contador C and Llobet R and Pollán M},
doi = {10.1136/oemed-2017-104580},
issn = {1470-7926},
year = {2018},
date = {2018-02-01},
journal = {Occup Environ Med},
volume = {75},
number = {2},
pages = {124--131},
abstract = {OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.nnMETHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.nnRESULTS: Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (e=1.51; 95% CI 1.04 to 2.19), ionising radiation (e=1.23; 95% CI 0.99 to 1.52) and mould spores (e=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation.nnCONCLUSIONS: Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.nnMETHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.nnRESULTS: Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (e=1.51; 95% CI 1.04 to 2.19), ionising radiation (e=1.23; 95% CI 0.99 to 1.52) and mould spores (e=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation.nnCONCLUSIONS: Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.
Benito L, de la Cueva Ariza L, Delgado-Hito P, Martinez Momblan MA, Romero García M, García M.
Identifying Coordination and Continuity of Care Indicators for Population-Based Cancer Screening Programs: A Delphi Study. Journal Article
Nurs Res. 2018;67:411–418.
Abstract | Links | BibTeX | Tags:
@article{pmid30052593,
title = {Identifying Coordination and Continuity of Care Indicators for Population-Based Cancer Screening Programs: A Delphi Study},
author = {Benito L and de la Cueva Ariza L and Delgado-Hito P and Martinez Momblan MA and Romero García M and García M},
doi = {10.1097/NNR.0000000000000300},
issn = {1538-9847},
year = {2018},
date = {2018-01-01},
journal = {Nurs Res},
volume = {67},
number = {5},
pages = {411--418},
abstract = {BACKGROUND: Continuity of care and care coordination are critical issues in virtually all healthcare systems. European guidelines for the quality of screening programs for breast and colorectal cancer describe process, structure, and outcome indicators, but none specifically evaluate coordination and continuity of care during the cancer screening process.nnOBJECTIVE: The aim of this study was to identify indicators reflecting care coordination and continuity in population-based breast and colorectal cancer screening program.nnMETHODS: A two-round Delphi study was conducted in a sample of 30 cancer screening nurses to identify quality indicators.nnRESULTS: The final Delphi consensus resulted in six core indicators for the cancer screening program: adequacy of the referral of the target population from the screening program to other health services, waiting time for referral to other health services, understanding of the screening program by professionals involved in the process, effective information flow between professionals involved in the process, participants' perception of the screening program, and, finally, participants' understanding of information about the program.nnCONCLUSION: The evaluation of indicators is crucial for quality improvement and should allow a measuring system to be established that would allow a comparison of outcomes for all population-based cancer screening programs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Continuity of care and care coordination are critical issues in virtually all healthcare systems. European guidelines for the quality of screening programs for breast and colorectal cancer describe process, structure, and outcome indicators, but none specifically evaluate coordination and continuity of care during the cancer screening process.nnOBJECTIVE: The aim of this study was to identify indicators reflecting care coordination and continuity in population-based breast and colorectal cancer screening program.nnMETHODS: A two-round Delphi study was conducted in a sample of 30 cancer screening nurses to identify quality indicators.nnRESULTS: The final Delphi consensus resulted in six core indicators for the cancer screening program: adequacy of the referral of the target population from the screening program to other health services, waiting time for referral to other health services, understanding of the screening program by professionals involved in the process, effective information flow between professionals involved in the process, participants' perception of the screening program, and, finally, participants' understanding of information about the program.nnCONCLUSION: The evaluation of indicators is crucial for quality improvement and should allow a measuring system to be established that would allow a comparison of outcomes for all population-based cancer screening programs.
Fu M, Travier N, Martín-Sánchez JC, Martínez-Sánchez JM, Vidal C, Garcia M, research LUCAPREV group.
Identifying high-risk individuals for lung cancer screening: Going beyond NLST criteria. Journal Article
PLoS One. 2018;13:e0195441.
Abstract | Links | BibTeX | Tags:
@article{pmid29621354,
title = {Identifying high-risk individuals for lung cancer screening: Going beyond NLST criteria},
author = {Fu M and Travier N and Martín-Sánchez JC and Martínez-Sánchez JM and Vidal C and Garcia M and LUCAPREV research group},
doi = {10.1371/journal.pone.0195441},
issn = {1932-6203},
year = {2018},
date = {2018-01-01},
journal = {PLoS One},
volume = {13},
number = {4},
pages = {e0195441},
abstract = {BACKGROUND: There are two main types of strategies to identify target population for lung cancer screening: 1) strategies based on age and cumulative smoking criteria, 2) risk prediction models allowing the calculation of an individual risk. The objective of this study was to compare different strategies to identify the proportion of the Spanish population at high risk of developing lung cancer, susceptible to be included in a lung cancer screening programme.nnMETHODS: Cross-sectional study. We used the data of the Spanish National Interview Health Survey (ENSE) of 2011-2012 (21,006 individuals) to estimate the proportion of participants at high risk of developing lung cancer. This estimation was performed using the U.S. national lung screening trial (NLST) criteria and a 6-year prediction model (PLCOm2012), both independently and in combination.nnRESULTS: The prevalence of individuals at high risk of developing lung cancer according to the NLST criteria was 4.9% (7.9% for men, 2.4% for women). Among the 1,034 subjects who met the NLST criteria, 533 (427 men and 106 women) had a 6-year lung cancer risk ≥2.0%. The combination of these two selection strategies showed that 2.5% of the Spanish population had a high risk of developing lung cancer. However, this selection process did not take into account different groups of subjects <75 years old having an individual risk of lung cancer ≥2%, such as heavy smokers <55 years old who were long-time former smokers, and ever-smokers having smoked <30 pack-years with other risk factors.nnCONCLUSIONS: Further research is needed to determine which selection strategy achieves a higher benefit/harm ratio and to assess other prevention strategies for individuals with elevated risk for lung cancer but who do not meet the screening eligibility criteria.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: There are two main types of strategies to identify target population for lung cancer screening: 1) strategies based on age and cumulative smoking criteria, 2) risk prediction models allowing the calculation of an individual risk. The objective of this study was to compare different strategies to identify the proportion of the Spanish population at high risk of developing lung cancer, susceptible to be included in a lung cancer screening programme.nnMETHODS: Cross-sectional study. We used the data of the Spanish National Interview Health Survey (ENSE) of 2011-2012 (21,006 individuals) to estimate the proportion of participants at high risk of developing lung cancer. This estimation was performed using the U.S. national lung screening trial (NLST) criteria and a 6-year prediction model (PLCOm2012), both independently and in combination.nnRESULTS: The prevalence of individuals at high risk of developing lung cancer according to the NLST criteria was 4.9% (7.9% for men, 2.4% for women). Among the 1,034 subjects who met the NLST criteria, 533 (427 men and 106 women) had a 6-year lung cancer risk ≥2.0%. The combination of these two selection strategies showed that 2.5% of the Spanish population had a high risk of developing lung cancer. However, this selection process did not take into account different groups of subjects <75 years old having an individual risk of lung cancer ≥2%, such as heavy smokers <55 years old who were long-time former smokers, and ever-smokers having smoked <30 pack-years with other risk factors.nnCONCLUSIONS: Further research is needed to determine which selection strategy achieves a higher benefit/harm ratio and to assess other prevention strategies for individuals with elevated risk for lung cancer but who do not meet the screening eligibility criteria.
Benito L, Farre A, Binefa G, Vidal C, Cardona A, Pla M, García M.
Factors related to longitudinal adherence in colorectal cancer screening: qualitative research findings. Journal Article
Cancer Causes Control. 2018;29:103–114.
Abstract | Links | BibTeX | Tags:
@article{pmid29170881,
title = {Factors related to longitudinal adherence in colorectal cancer screening: qualitative research findings},
author = {Benito L and Farre A and Binefa G and Vidal C and Cardona A and Pla M and García M},
doi = {10.1007/s10552-017-0982-z},
issn = {1573-7225},
year = {2018},
date = {2018-01-01},
journal = {Cancer Causes Control},
volume = {29},
number = {1},
pages = {103--114},
abstract = {BACKGROUND: The effectiveness of screening in colorectal cancer prevention depends on sustained participation rates. The objective of this study was to explore factors related to the longitudinal adherence of screening behavior in the context of a biennial population-based cancer screening program.nnMETHODS: Eight focus groups were conducted with individuals who were invited two or three consecutive times to a population-based colorectal cancer screening program using a fecal occult blood test and who agreed to participate in the program at least once (n = 45). The criteria used to select the study members included adherence to fecal occult blood test maintenance, factors regarding their initial participation in the colorectal cancer screening, sex, and contextual educational level.nnRESULTS: The participants expressed a high level of satisfaction with the program; however, they showed a low level of understanding with respect to cancer screening. Consulting a general practitioner was cited by all participants as an important factor that mediated their final decision or influenced their behavior as a whole with regard to the program. Fear played a different role in the screening behavior for regular and irregular adherent participants. In the adherent participants, fear facilitated their continued participation in the screening program, whereas for the irregular participants, fear led them to avoid or refuse further screening. Having a close person diagnosed with colorectal cancer was a facilitator for the regular adherent participants. The irregular adherent participants showed some relaxation with respect to screening after a negative result and considered that further screening was no longer necessary.nnCONCLUSION: Considering the importance of primary healthcare professionals in the decision regarding sustained participation, it is important to better engage them with cancer screening programs, as well as improve the communication channels to provide accurate and balanced information for both health professionals and individuals.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: The effectiveness of screening in colorectal cancer prevention depends on sustained participation rates. The objective of this study was to explore factors related to the longitudinal adherence of screening behavior in the context of a biennial population-based cancer screening program.nnMETHODS: Eight focus groups were conducted with individuals who were invited two or three consecutive times to a population-based colorectal cancer screening program using a fecal occult blood test and who agreed to participate in the program at least once (n = 45). The criteria used to select the study members included adherence to fecal occult blood test maintenance, factors regarding their initial participation in the colorectal cancer screening, sex, and contextual educational level.nnRESULTS: The participants expressed a high level of satisfaction with the program; however, they showed a low level of understanding with respect to cancer screening. Consulting a general practitioner was cited by all participants as an important factor that mediated their final decision or influenced their behavior as a whole with regard to the program. Fear played a different role in the screening behavior for regular and irregular adherent participants. In the adherent participants, fear facilitated their continued participation in the screening program, whereas for the irregular participants, fear led them to avoid or refuse further screening. Having a close person diagnosed with colorectal cancer was a facilitator for the regular adherent participants. The irregular adherent participants showed some relaxation with respect to screening after a negative result and considered that further screening was no longer necessary.nnCONCLUSION: Considering the importance of primary healthcare professionals in the decision regarding sustained participation, it is important to better engage them with cancer screening programs, as well as improve the communication channels to provide accurate and balanced information for both health professionals and individuals.
Benito L, Espinosa J, Binefa G, Vidal C, Lluch MT, Puig M, Fernandez M, Padrol I, García M.
Population-based Cancer Screening: Measurement of Coordination and Continuity of Care. Journal Article
Cancer Nurs. 2018;41:E1–E11.
Abstract | Links | BibTeX | Tags:
@article{pmid28622194,
title = {Population-based Cancer Screening: Measurement of Coordination and Continuity of Care},
author = {Benito L and Espinosa J and Binefa G and Vidal C and Lluch MT and Puig M and Fernandez M and Padrol I and García M},
doi = {10.1097/NCC.0000000000000514},
issn = {1538-9804},
year = {2018},
date = {2018-01-01},
journal = {Cancer Nurs},
volume = {41},
number = {4},
pages = {E1--E11},
abstract = {BACKGROUND: European guidelines for the quality of screening programs for breast and colorectal cancer describe process, structure, and outcome indicators. However, none of them specifically evaluate coordination and continuity of care during the cancer screening process.nnOBJECTIVES: The aim of this study was to identify and adapt care quality indicators related to the coordination and continuity of the cancer screening process to assess nursing care in cancer screening programs.nnMETHODS: The indicators proposed in this study were selected in 2 phases. The first consisted of a literature review, and the second was made by consensus of an expert group. An electronic literature search was conducted, through June 2016. From a total of 225 articles retrieved, 14 studies met inclusion criteria, and these 14 documents were delivered to the group of experts for evaluation and to propose a final list of agreed-upon indicators.nnRESULTS: The group of experts selected 7 indicators: adequacy and waiting time derivation of participants, delivery and availability of the report of the process, understanding professionals involved in the process, and satisfaction and understanding of participants.nnCONCLUSIONS: These indicators should help identify areas for improvement and measure the outcome of coordination and continuity of care.nnIMPLICATIONS FOR PRACTICE: The results provided a common set of indicators to evaluate the coordination and continuity of care for cancer screening and to consequently assess the contribution of nursing care in cancer screening programs. The identification and adaptation of these quality indicators will help to identify areas for improvement and measure the effect of coordination and continuity of care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: European guidelines for the quality of screening programs for breast and colorectal cancer describe process, structure, and outcome indicators. However, none of them specifically evaluate coordination and continuity of care during the cancer screening process.nnOBJECTIVES: The aim of this study was to identify and adapt care quality indicators related to the coordination and continuity of the cancer screening process to assess nursing care in cancer screening programs.nnMETHODS: The indicators proposed in this study were selected in 2 phases. The first consisted of a literature review, and the second was made by consensus of an expert group. An electronic literature search was conducted, through June 2016. From a total of 225 articles retrieved, 14 studies met inclusion criteria, and these 14 documents were delivered to the group of experts for evaluation and to propose a final list of agreed-upon indicators.nnRESULTS: The group of experts selected 7 indicators: adequacy and waiting time derivation of participants, delivery and availability of the report of the process, understanding professionals involved in the process, and satisfaction and understanding of participants.nnCONCLUSIONS: These indicators should help identify areas for improvement and measure the outcome of coordination and continuity of care.nnIMPLICATIONS FOR PRACTICE: The results provided a common set of indicators to evaluate the coordination and continuity of care for cancer screening and to consequently assess the contribution of nursing care in cancer screening programs. The identification and adaptation of these quality indicators will help to identify areas for improvement and measure the effect of coordination and continuity of care.